Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PDE6A | P16499 | 2/20 | 0.42 |
| ▸ | PDE6B | P35913 | 2/20 | 0.42 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415204 | 0.80 | HSD17B10 (0.53) | HSD17B10HPGDHTTGRIN1GRIN2B | |
| SCHEMBL19657540 | 0.76 | HSD17B10 (0.65) | HSD17B10HPGDHTTGRIN1GRIN2B | |
| SCHEMBL25407471 | 0.74 | HSD17B10 (0.62) | HSD17B10HPGDHTTPDE4D | |
| SCHEMBL3513392 | 0.74 | HSD17B10 (1.00) | HSD17B10HPGDHTTPDE4D | |
| SCHEMBL30349792 | 0.74 | HSD17B10 (0.62) | HSD17B10HPGDHTTPDE4D | |
| SCHEMBL12136691 | 0.72 | RAB9A (0.57) | HSD17B10HTTRAB9ANPC1 | |
| SCHEMBL11922125 | 0.71 | HSD17B10 (0.59) | HSD17B10HPGDHTTGRIN1GRIN2B | |
| SCHEMBL21024080 | 0.71 | HSD17B10 (0.59) | HSD17B10HPGDHTTPDE6APDE6B | |
| SCHEMBL25606475 | 0.71 | PDE6A (0.38) | HSD17B10HPGDHTTPDE6APDE6B | |
| SCHEMBL19657844 | 0.70 | RAB9A (0.39) | HSD17B10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |