Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657852 | 0.84 | BRD4 (0.46) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL19657743 | 0.84 | BRD4 (0.46) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL22822511 | 0.81 | BRD4 (0.43) | BRD4NR4A2CREBBPMAOB | |
| SCHEMBL30993088 | 0.74 | BRD4 (0.44) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL19657855 | 0.74 | NR4A2 (0.64) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL30993572 | 0.73 | BRD4 (0.47) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL19657311 | 0.72 | BRD4 (0.48) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL20674106 | 0.70 | BRD4 (0.39) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL22822275 | 0.69 | BRD4 (0.44) | BRD4NR4A2CREBBPMAP2K1MAP2K2 | |
| SCHEMBL21516789 | 0.68 | KDM4E (0.44) | MAP2K1MAP2K2SMN1; SMN2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |