Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30993004 | 0.84 | CREBBP (0.45) | CREBBPNR4A2BRD4TRIM24EP300 | |
| SCHEMBL21024069 | 0.82 | CREBBP (0.41) | CREBBPBRD4TRIM24EP300BRD3 | |
| SCHEMBL21024070 | 0.75 | CREBBP (0.40) | CREBBPCYP3A4NR4A2BRD4TRIM24 | |
| SCHEMBL27102751 | 0.73 | GAA (0.36) | ALDH1A1 | |
| SCHEMBL30993379 | 0.72 | CREBBP (0.41) | CREBBPNR4A2BRD4TRIM24EP300 | |
| SCHEMBL27102748 | 0.71 | GAA (0.40) | ALDH1A1 | |
| SCHEMBL19657314 | 0.70 | CREBBP (0.44) | CREBBPNR4A2BRD4LMNAALDH1A1 | |
| SCHEMBL16661684 | 0.70 | NR4A2 (0.68) | NR4A2LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL21024066 | 0.69 | CREBBP (0.43) | CREBBPCYP3A4BRD4TRIM24EP300 | |
| SCHEMBL22822512 | 0.69 | CREBBP (0.35) | CREBBPCYP3A4BRD4TRIM24EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |