Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153299 | 0.83 | UHRF1 (0.40) | CCR1RAB9ACCR5GAAKMT2A | |
| SCHEMBL19657739 | 0.74 | HTR3A (0.33) | — | |
| SCHEMBL12680341 | 0.71 | XIAP (0.38) | — | |
| SCHEMBL12680350 | 0.71 | XIAP (0.50) | RAB9AKMT2A | |
| SCHEMBL14643852 | 0.68 | UHRF1 (0.34) | UHRF1 | |
| SCHEMBL18865507 | 0.68 | PDK2 (0.32) | — | |
| SCHEMBL13400071 | 0.64 | CCR1 (0.34) | CCR1RAB9ACCR5GAAKMT2A | |
| SCHEMBL7920476 | 0.64 | CCR1 (0.34) | CCR1RAB9ACCR5GAAKMT2A | |
| SCHEMBL279310 | 0.64 | UHRF1 (0.43) | CCR1RAB9ACCR5UHRF1 | |
| SCHEMBL24046845 | 0.63 | GRM5 (0.33) | CCR1RAB9ACCR5GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |