Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529059 | 1.00 | — | — | |
| SCHEMBL7293300 | 0.93 | PAOX (0.50) | MAPTPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9290140 | 0.91 | ALDH1A1 (0.68) | MAPTPOLBALDH1A1L3MBTL1HTT | |
| SCHEMBL805515 | 0.89 | ALDH1A1 (0.72) | MAPTPOLBALDH1A1L3MBTL1HTT | |
| SCHEMBL25066673 | 0.86 | ALDH1A1 (0.42) | MAPTPOLBALDH1A1PAOXSMN1; SMN2 | |
| SCHEMBL22414126 | 0.86 | MAPT (0.42) | MAPTPOLBALDH1A1L3MBTL1PAOX | |
| SCHEMBL21100445 | 0.86 | MAPT (0.42) | MAPTPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL14002787 | 0.85 | GLA (0.60) | MAPTPOLBALDH1A1PAOXGLA | |
| SCHEMBL27888690 | 0.83 | POLB (0.58) | MAPTPOLBALDH1A1L3MBTL1PKM | |
| Hydrochloric Acid SCHEMBL28044317 | 0.78 | ALDH1A1 (0.58) | MAPTPOLBALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205309-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-30 | — | — | WO | disclosed |