Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TAF1 | P21675 | 2/20 | 0.51 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20544126 | 0.90 | CYP2C19 (0.52) | CYP2C19TAF1CECR2BRD9RIPK1 | |
| SCHEMBL19652213 | 0.87 | CYP2C19 (0.49) | CYP2C19TAF1CECR2BRD9RIPK1 | |
| SCHEMBL16855309 | 0.85 | TAF1 (0.47) | CYP2C19TAF1CECR2BRD9RIPK1 | |
| SCHEMBL18199170 | 0.81 | TAF1 (0.44) | CYP2C19TAF1CECR2BRD9RIPK1 | |
| SCHEMBL19658786 | 0.80 | TAF1 (0.51) | TAF1CECR2BRD9MAP4K4ITGB2 | |
| SCHEMBL19658497 | 0.80 | MAP4K4 (0.45) | TAF1CECR2BRD9MAP4K4ITGB2 | |
| SCHEMBL16855354 | 0.80 | TAF1 (0.46) | CYP2C19TAF1CECR2BRD9RIPK1 | |
| SCHEMBL16855312 | 0.80 | TAF1 (0.42) | CYP2C19TAF1CECR2BRD9RIPK1 | |
| SCHEMBL16855557 | 0.79 | TAF1 (0.45) | CYP2C19TAF1CECR2BRD9RIPK1 | |
| SCHEMBL19658489 | 0.78 | MAP4K4 (0.43) | TAF1CECR2BRD9MAP4K4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | CYP2C19 4039/4885TAF1 439/4885CECR2 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.