Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 2/20 | 0.51 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | LCAT | P04180 | 2/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.42 |
| ▸ | ITGAL | P20701 | 3/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19652260 | 0.87 | TAF1 (0.51) | TAF1CECR2BRD9LCATACACB | |
| SCHEMBL19658407 | 0.80 | CYP2C19 (0.52) | TAF1CECR2BRD9MAP4K4ACACB | |
| SCHEMBL19658497 | 0.80 | MAP4K4 (0.45) | TAF1CECR2BRD9MAP4K4ACACB | |
| SCHEMBL16648636 | 0.79 | ITGB2 (0.47) | LCATACACBPARP1ITGB2ICAM1 | |
| SCHEMBL19658489 | 0.78 | MAP4K4 (0.43) | TAF1CECR2BRD9MAP4K4ACACB | |
| SCHEMBL19658510 | 0.76 | OPRD1 (0.47) | TAF1CECR2BRD9MAP4K4ITGB2 | |
| SCHEMBL19658782 | 0.76 | TAF1 (0.54) | TAF1CECR2BRD9MAP4K4ITGB2 | |
| SCHEMBL2277568 | 0.76 | LCAT (0.45) | TAF1CECR2BRD9LCATACACB | |
| SCHEMBL19658736 | 0.75 | GPR119 (0.52) | TAF1CECR2BRD9MAP4K4PARP1 | |
| SCHEMBL18544729 | 0.75 | MAP4K4 (0.50) | MAP4K4LCATPARP1CCR2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | TAF1 439/4885CECR2 184/4885BRD9 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.