Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 18/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22888275 | 0.92 | RIPK1 (0.65) | RIPK1 | |
| SCHEMBL18366976 | 0.89 | RIPK1 (0.58) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19659284 | 0.87 | RIPK1 (0.56) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18366974 | 0.84 | RIPK1 (0.53) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18367182 | 0.81 | RIPK1 (0.67) | RIPK1 | |
| SCHEMBL19641606 | 0.81 | RIPK1 (0.67) | RIPK1 | |
| SCHEMBL21886900 | 0.79 | RIPK1 (0.48) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22888078 | 0.79 | RIPK1 (0.47) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22209175 | 0.77 | RIPK1 (0.63) | RIPK1 | |
| SCHEMBL22209176 | 0.77 | RIPK1 (0.63) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |