Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367368 | 0.90 | POLB (0.33) | BACE1BACE2RIPK1APPCYP3A4 | |
| SCHEMBL22888406 | 0.89 | BACE1 (0.32) | BACE1BACE2RIPK1APPCYP3A4 | |
| SCHEMBL19659484 | 0.87 | — | — | |
| SCHEMBL18367374 | 0.87 | NPC1 (0.32) | BACE1BACE2APPCYP3A4 | |
| SCHEMBL30587563 | 0.78 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL22887768 | 0.78 | — | — | |
| SCHEMBL27205418 | 0.70 | RIPK1 (0.62) | RIPK1 | |
| SCHEMBL22887935 | 0.70 | RIPK1 (0.35) | RIPK1 | |
| SCHEMBL18367366 | 0.69 | RIPK1 (0.45) | BACE1BACE2RIPK1APPCYP3A4 | |
| SCHEMBL30092674 | 0.69 | RIPK1 (0.45) | BACE1BACE2RIPK1APPCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |