Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234233 | 0.85 | NOTUM (0.50) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL5234227 | 0.85 | NOTUM (0.50) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL5234219 | 0.85 | NOTUM (0.50) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL20749828 | 0.78 | NOTUM (0.64) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL8244060 | 0.77 | NOTUM (0.68) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL16281586 | 0.75 | NOTUM (0.70) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL21233478 | 0.72 | MAOA (0.59) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL27388745 | 0.71 | NOTUM (0.54) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL30539318 | 0.71 | NOTUM (1.00) | NOTUMALDH1A1MAPTTAAR1ALOX15 | |
| SCHEMBL3210469 | 0.71 | NOTUM (1.00) | NOTUMALDH1A1MAPTTAAR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205193-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS GPR120 AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-30 | — | — | WO | disclosed |