Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 19/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19643965 | 0.86 | CREBBP (0.47) | CREBBPBRD4CCNCCDK8EP300 | |
| SCHEMBL21237550 | 0.86 | CREBBP (0.47) | CREBBPBRD4EP300 | |
| SCHEMBL19663200 | 0.86 | CREBBP (0.47) | CREBBPBRD4EP300 | |
| SCHEMBL30878013 | 0.86 | CREBBP (0.47) | CREBBPBRD4CCNCCDK8EP300 | |
| SCHEMBL21237382 | 0.84 | CREBBP (0.45) | CREBBPBRD4EP300 | |
| SCHEMBL21419225 | 0.84 | CREBBP (0.49) | CREBBPBRD4EP300 | |
| SCHEMBL24368131 | 0.82 | CREBBP (0.44) | CREBBPBRD4EP300 | |
| SCHEMBL19643357 | 0.78 | CREBBP (0.42) | CREBBPBRD4EP300 | |
| SCHEMBL30878068 | 0.78 | CREBBP (0.42) | CREBBPBRD4EP300 | |
| SCHEMBL17794959 | 0.77 | CREBBP (0.47) | CREBBPBRD4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |