Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1B | P36896 | 12/20 | 1.00 |
| ▸ | KDR | P35968 | 6/20 | 1.00 |
| ▸ | TGFBR1 | P36897 | 6/20 | 1.00 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 1.00 |
| ▸ | TGFBR2 | P37173 | 5/20 | 1.00 |
| ▸ | BMPR2 | Q13873 | 4/20 | 1.00 |
| ▸ | ACVR1 | Q04771 | 12/20 | 0.79 |
| ▸ | ACVRL1 | P37023 | 10/20 | 0.79 |
| ▸ | BMPR1B | O00238 | 9/20 | 0.79 |
| ▸ | BMPR1A | P36894 | 8/20 | 0.79 |
| ▸ | BMP4 | P12644 | 7/20 | 0.79 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.79 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.79 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060174 | 1.00 | ACVR1B (1.00) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| SCHEMBL29389388 | 0.90 | ACVR1B (0.83) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| SCHEMBL17817805 | 0.90 | ACVR1B (0.83) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| SCHEMBL11954476 | 0.89 | ACVR1B (0.81) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| SCHEMBL31060242 | 0.89 | ACVR1B (1.00) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| SCHEMBL456393 | 0.88 | ACVR1 (1.00) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| SCHEMBL29353046 | 0.88 | ACVR1 (1.00) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| Hydrochloric Acid SCHEMBL2059683 | 0.87 | ACVR1 (0.98) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| Hydrochloric Acid SCHEMBL22462135 | 0.87 | ACVR1 (0.98) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 | |
| Hydrochloric Acid SCHEMBL29634729 | 0.87 | ACVR1 (0.98) | ACVR1BKDRTGFBR1PRKAB1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230332107-A1 | CELL THERAPY FOR DIABETES | VERTEX PHARMACEUTICALS INCORPORATED | 2023-10-19 | — | — | US | disclosed |
| WO-2017205746-A1 | METHODS OF DIFFERENTIATING STEM CELL-DERIVED PROPRIOCEPTORS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-11-30 | — | — | WO | disclosed |