Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.54 |
| ▸ | PNP | P00491 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23734167 | 1.00 | POLA1 (0.54) | POLA1PNPLMNATP53HTT | |
| SCHEMBL29455222 | 1.00 | POLA1 (0.54) | POLA1PNPLMNATP53HTT | |
| SCHEMBL22571146 | 1.00 | POLA1 (0.54) | POLA1PNPLMNATP53HTT | |
| SCHEMBL17222408 | 0.89 | POLA1 (0.53) | POLA1PNPLMNATP53HTT | |
| SCHEMBL17222404 | 0.89 | POLA1 (0.53) | POLA1PNPLMNATP53HTT | |
| SCHEMBL5059377 | 0.88 | POLA1 (0.58) | POLA1PNPLMNATP53HTT | |
| SCHEMBL19662721 | 0.87 | POLB (0.47) | POLA1PNPLMNATP53HTT | |
| SCHEMBL26156310 | 0.86 | KDM4E (0.51) | POLA1PNPLMNATP53HTT | |
| SCHEMBL19662716 | 0.86 | POLB (0.46) | POLA1PNPLMNATP53HTT | |
| SCHEMBL20684464 | 0.85 | POLA1 (0.54) | POLA1PNPLMNATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205336-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-30 | — | — | WO | disclosed |