Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662793 | 1.00 | CREBBP (0.49) | CREBBPLRRK2ABCG2CDK4PDE10A | |
| SCHEMBL23761896 | 1.00 | CREBBP (0.49) | CREBBPLRRK2ABCG2CDK4PDE10A | |
| SCHEMBL21237477 | 0.85 | CREBBP (0.47) | CREBBPLRRK2ABCG2CDK4PDE10A | |
| SCHEMBL21237185 | 0.85 | CREBBP (0.46) | CREBBPLRRK2ABCG2CDK4PDE10A | |
| SCHEMBL24368149 | 0.85 | CREBBP (0.47) | CREBBPLRRK2ABCG2CDK4ADRA1A | |
| SCHEMBL21237184 | 0.85 | CREBBP (0.46) | CREBBPLRRK2ABCG2CDK4PDE10A | |
| SCHEMBL23762011 | 0.84 | CREBBP (0.47) | CREBBPCDK4PDE10A | |
| SCHEMBL19662984 | 0.84 | CREBBP (0.47) | CREBBPCDK4PDE10A | |
| SCHEMBL19662997 | 0.84 | CREBBP (0.47) | CREBBPCDK4PDE10A | |
| SCHEMBL19662787 | 0.84 | CREBBP (0.47) | CREBBPLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |