Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662984 | 1.00 | CREBBP (0.47) | CREBBPSMPD3KDM4EMAPTKMT2A | |
| SCHEMBL23762011 | 1.00 | CREBBP (0.47) | CREBBPSMPD3KDM4EMAPTKMT2A | |
| SCHEMBL19662787 | 0.87 | CREBBP (0.47) | CREBBPHTR3A | |
| SCHEMBL21237243 | 0.84 | CREBBP (0.43) | CREBBPSMPD3KMT2ALMNAHTR3A | |
| SCHEMBL21237247 | 0.84 | CREBBP (0.43) | CREBBPSMPD3KMT2ALMNAHTR3A | |
| SCHEMBL19662775 | 0.84 | CREBBP (0.49) | CREBBPPDE10ACDK4 | |
| SCHEMBL19662788 | 0.84 | HRH4 (0.49) | — | |
| SCHEMBL23761896 | 0.84 | CREBBP (0.49) | CREBBPPDE10ACDK4 | |
| SCHEMBL19662793 | 0.84 | CREBBP (0.49) | CREBBPPDE10ACDK4 | |
| SCHEMBL19662790 | 0.83 | CREBBP (0.50) | CREBBPHTR3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |