Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | KCNK3 | O14649 | 5/20 | 0.65 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.64 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.64 |
| ▸ | NT5E | P21589 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GRM5 | P41594 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252916 | 0.87 | KCNK3 (0.72) | TP53NPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL14825225 | 0.86 | SCN10A (0.60) | NPC1RAB9AKCNH2MEN1KMT2A | |
| SCHEMBL9587298 | 0.86 | MEN1 (0.65) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL259705 | 0.85 | MEN1 (0.65) | TP53NPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL27383419 | 0.85 | NPC1 (0.63) | TP53NPC1RAB9AP2RY2GPR17 | |
| SCHEMBL4257440 | 0.84 | NPC1 (0.81) | TP53NPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL30048093 | 0.84 | NPC1 (0.81) | TP53NPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL12700258 | 0.84 | MEN1 (0.69) | TP53NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9057146 | 0.82 | NPC1 (0.65) | TP53NPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL5380687 | 0.81 | TP53 (1.00) | TP53NPC1RAB9AKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247989-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2022-02-15 | — | — | US | disclosed |
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2019-08-08 | — | — | US | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11247989-B2 | Therapeutic compounds and uses thereof | EP300, HDAC1, CREBBP | TP53 2251/4885NPC1 387/4885RAB9A 3405/4885 |
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, CREBBP | TP53 2251/4885NPC1 387/4885RAB9A 3405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.