Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19663194 | 0.86 | PIM1 (0.46) | PIM1CREBBPMAPTMAP4K1CYP11B1 | |
| SCHEMBL19663181 | 0.86 | CREBBP (0.45) | PIM1CREBBPMAPTMAP4K1CYP11B1 | |
| SCHEMBL21237384 | 0.84 | PIM1 (0.42) | PIM1CREBBPMAPTMAP4K1CYP11B1 | |
| SCHEMBL19660444 | 0.83 | PIM1 (0.48) | PIM1CREBBPMAPTMAP4K1CYP11B1 | |
| SCHEMBL19662994 | 0.82 | FGFR3 (0.47) | PIM1CREBBPMAPTMAP4K1PIM3 | |
| SCHEMBL24367838 | 0.81 | CREBBP (0.42) | PIM1CREBBPMAPTMAP4K1CYP11B1 | |
| SCHEMBL19660440 | 0.77 | CREBBP (0.57) | PIM1CREBBPMAPTPIM3PIM2 | |
| SCHEMBL23762167 | 0.77 | CYP11B1 (0.47) | PIM1CREBBPMAPTCYP11B1CYP11B2 | |
| SCHEMBL19660420 | 0.75 | PIM1 (0.46) | PIM1CREBBPMAPTMAP4K1CYP11B1 | |
| SCHEMBL19662765 | 0.71 | PIM1 (0.50) | PIM1CREBBPMAPTMAP4K1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |