Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 9/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.42 |
| ▸ | WNT1 | P04628 | 8/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25646429 | 0.82 | GSK3B (0.57) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL14906787 | 0.79 | CYP11B1 (0.60) | CYP11B1CYP11B2PIM1MAPK1MKNK1 | |
| SCHEMBL19662951 | 0.79 | PIM1 (0.53) | PIM1MAPK1FGFR3KDRMAPT | |
| SCHEMBL19663194 | 0.78 | PIM1 (0.46) | CYP11B1CYP11B2PIM1MAPTCREBBP | |
| SCHEMBL19663181 | 0.78 | CREBBP (0.45) | CYP11B1CYP11B2PIM1MAPTCREBBP | |
| SCHEMBL19663003 | 0.77 | PIM1 (0.43) | CYP11B1CYP11B2PIM1FGFR3KDR | |
| SCHEMBL21237384 | 0.76 | PIM1 (0.42) | CYP11B1CYP11B2PIM1FGFR3KDR | |
| SCHEMBL19660427 | 0.74 | PIM1 (0.45) | PIM1MKNK1FGFR3KDRMAPT | |
| SCHEMBL24367838 | 0.74 | CREBBP (0.42) | CYP11B1CYP11B2PIM1FGFR3KDR | |
| SCHEMBL20951240 | 0.74 | PIM1 (0.47) | PIM1MAPK1FGFR3KDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |