Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19660465 | 0.99 | MEN1 (0.48) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL19643632 | 0.82 | MAPT (0.46) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL19662990 | 0.82 | POLB (0.42) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL21237182 | 0.82 | CREBBP (0.41) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL24367777 | 0.82 | CREBBP (0.43) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL21237206 | 0.81 | CREBBP (0.42) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL21237209 | 0.79 | CREBBP (0.41) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL24368127 | 0.77 | CREBBP (0.40) | MEN1KMT2ACREBBPPARP1POLB | |
| SCHEMBL23004922 | 0.76 | OPRM1 (0.49) | MEN1KMT2APARP1POLBHTT | |
| SCHEMBL30278373 | 0.76 | OPRM1 (0.49) | MEN1KMT2APARP1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |