Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | UTRN | P46939 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2242151 | 0.92 | SMN1; SMN2 (0.71) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2240335 | 0.88 | NPC1 (0.70) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2246997 | 0.87 | NPC1 (0.73) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2242964 | 0.86 | SMN1; SMN2 (0.74) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2245441 | 0.85 | CASP3 (0.75) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2243066 | 0.84 | CASP3 (0.74) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2247011 | 0.83 | NPC1 (0.74) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2242010 | 0.83 | NPC1 (0.77) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2243398 | 0.82 | CASP3 (0.87) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2242920 | 0.82 | SMN1; SMN2 (0.80) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3251694-A1 | DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | Summit (Oxford) Limited (GB) | 2017-12-06 | — | — | EP | disclosed |