Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19664596 | 0.85 | SYK (0.44) | SYK | |
| SCHEMBL16778213 | 0.85 | SYK (0.61) | SYK | |
| SCHEMBL19664606 | 0.81 | IDH2 (0.50) | SYK | |
| SCHEMBL16778129 | 0.76 | SYK (0.49) | SYK | |
| SCHEMBL15571140 | 0.75 | SYK (0.57) | SYK | |
| SCHEMBL19664621 | 0.75 | SYK (0.47) | SYK | |
| SCHEMBL16778225 | 0.74 | SYK (0.57) | SYK | |
| SCHEMBL19664598 | 0.74 | SYK (0.45) | SYK | |
| SCHEMBL15570056 | 0.73 | SYK (0.58) | SYK | |
| SCHEMBL16778180 | 0.72 | SYK (0.58) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2863915-B1 | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | claimed |
| EP-2863915-B1 | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | disclosed |