Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 5/20 | 0.50 |
| ▸ | SYK | P43405 | 15/20 | 0.49 |
| ▸ | IDH1 | O75874 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16778136 | 0.83 | SYK (0.60) | SYK | |
| SCHEMBL19664612 | 0.83 | SYK (0.47) | IDH2SYKIDH1ABCB11ADORA3 | |
| SCHEMBL19664591 | 0.81 | SYK (0.47) | SYK | |
| SCHEMBL19664621 | 0.80 | SYK (0.47) | SYK | |
| SCHEMBL19664598 | 0.79 | SYK (0.45) | SYK | |
| SCHEMBL16778129 | 0.77 | SYK (0.49) | SYK | |
| SCHEMBL16737592 | 0.75 | SYK (0.60) | SYK | |
| SCHEMBL17006606 | 0.73 | SYK (0.71) | SYK | |
| SCHEMBL15571140 | 0.72 | SYK (0.57) | SYK | |
| SCHEMBL16737452 | 0.72 | SYK (0.61) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2863915-B1 | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | claimed |