Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.47 |
| ▸ | IDH2 | P48735 | 3/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19664606 | 0.83 | IDH2 (0.50) | SYKIDH2IDH1ABCB11ADORA3 | |
| SCHEMBL16778136 | 0.82 | SYK (0.60) | SYK | |
| SCHEMBL19664596 | 0.81 | SYK (0.44) | SYK | |
| SCHEMBL19664623 | 0.79 | SYK (0.45) | SYK | |
| SCHEMBL19664602 | 0.78 | SYK (0.48) | SYK | |
| SCHEMBL16737592 | 0.74 | SYK (0.60) | SYK | |
| SCHEMBL21004550 | 0.73 | SYK (0.49) | SYK | |
| SCHEMBL19553899 | 0.72 | SYK (0.55) | SYK | |
| SCHEMBL16737452 | 0.71 | SYK (0.61) | SYK | |
| SCHEMBL16778167 | 0.69 | SYK (0.60) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2863915-B1 | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | claimed |