Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 19/20 | 0.42 |
| ▸ | MME | P08473 | 16/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2392577 | 0.89 | AGTR1 (0.43) | AGTR1MMEAGTR2 | |
| SCHEMBL2390591 | 0.84 | AGTR1 (0.45) | AGTR1MMEAGTR2 | |
| SCHEMBL1966829 | 0.78 | MME (0.65) | AGTR1MME | |
| SCHEMBL1258515 | 0.75 | MME (0.57) | AGTR1MME | |
| SCHEMBL1968577 | 0.73 | MME (0.67) | AGTR1MME | |
| SCHEMBL15422789 | 0.72 | AGTR1 (0.56) | AGTR1MME | |
| SCHEMBL1257539 | 0.71 | MME (0.67) | AGTR1MME | |
| SCHEMBL1258192 | 0.70 | MME (0.81) | AGTR1MME | |
| SCHEMBL6007263 | 0.69 | AGTR1 (0.58) | AGTR1AGTR2 | |
| SCHEMBL6005787 | 0.68 | AGTR1 (0.63) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334651-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010011821-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2010-01-28 | — | — | WO | disclosed |