Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19668268 | 0.89 | KLKB1 (0.66) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL28337073 | 0.84 | KLKB1 (0.56) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL19668489 | 0.84 | KLKB1 (0.71) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785380 | 0.83 | KLKB1 (0.69) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17785277 | 0.82 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL29835923 | 0.82 | KLKB1 (1.00) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL17784852 | 0.81 | KLKB1 (0.67) | KLKB1 | |
| SCHEMBL17785382 | 0.81 | KLKB1 (0.75) | KLKB1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL28339182 | 0.80 | KLKB1 (0.59) | KLKB1 | |
| SCHEMBL28339177 | 0.79 | F11 (0.70) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113387933-A | Pyrazole derivatives as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109311847-B | Pyrazole derivatives as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-107108576-B | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2020-03-10 | — | — | CN | disclosed |
| CN-110577519-A | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2019-12-17 | — | — | CN | disclosed |
| EP-3464271-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017207983-A1 | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2017-12-07 | — | — | WO | disclosed |