Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754714 | 1.00 | MAP4K4 (0.42) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL17778601 | 1.00 | MAP4K4 (0.42) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL16249990 | 1.00 | MAP4K4 (0.42) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL19365533 | 1.00 | MAP4K4 (0.42) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL16754580 | 0.97 | DGAT2 (0.41) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL16754489 | 0.97 | DGAT2 (0.41) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL16754343 | 0.97 | MAP4K4 (0.42) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL16754341 | 0.97 | MAP4K4 (0.42) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL16754344 | 0.97 | MAP4K4 (0.42) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 | |
| SCHEMBL17778529 | 0.97 | DGAT2 (0.41) | MAP4K4DGAT2TRPV1TRPV3EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |