Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.31 |
| ▸ | PTPRB | P23467 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865020 | 0.93 | RHOA (0.34) | RHOACA2CA9DDB1CRBN | |
| SCHEMBL19670152 | 0.90 | RHOA (0.36) | RHOACA2CA9HTR2CBRAF | |
| SCHEMBL20632034 | 0.87 | RHOA (0.41) | RHOACA2CA9HTR2CBRAF | |
| SCHEMBL17624671 | 0.85 | RHOA (0.38) | RHOACA2CA9DDB1CRBN | |
| SCHEMBL16785596 | 0.84 | RHOA (0.37) | RHOACA2CA9DDB1CRBN | |
| SCHEMBL19365614 | 0.84 | RHOA (0.35) | RHOACA2CA9DDB1CRBN | |
| SCHEMBL19705996 | 0.84 | RHOA (0.33) | RHOACA2CA9DDB1CRBN | |
| SCHEMBL19365224 | 0.83 | RHOA (0.35) | RHOACA2CA9HTR2CBRAF | |
| SCHEMBL19706159 | 0.81 | RHOA (0.36) | RHOACA2CA9CCR3BRAF | |
| SCHEMBL19670371 | 0.80 | NAMPT (0.44) | CA2CA9RORCPTPRBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |