Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670366 | 0.91 | NAMPT (0.42) | NAMPTPTPRBCA2CA9RORC | |
| SCHEMBL19699078 | 0.90 | NAMPT (0.42) | NAMPTPTPRBCA2CA9RORC | |
| SCHEMBL19365537 | 0.87 | CA2 (0.43) | CA2CA9MAPTFAAHLMNA | |
| SCHEMBL16776455 | 0.86 | NAMPT (0.43) | NAMPTPTPRBCA2CA9RORC | |
| SCHEMBL16776180 | 0.86 | NAMPT (0.42) | NAMPTPTPRBCA2CA9RORC | |
| SCHEMBL19365540 | 0.84 | CA2 (0.38) | NAMPTCA2CA9MAPTUSP2 | |
| SCHEMBL19670654 | 0.83 | CA2 (0.42) | CA2CA9RORCMAPTLMNA | |
| SCHEMBL19365797 | 0.83 | TP53 (0.38) | CA2CA9FAAHUSP2POLB | |
| SCHEMBL19670369 | 0.82 | NAMPT (0.41) | NAMPTPTPRBCA2CA9RORC | |
| SCHEMBL16250024 | 0.82 | NAMPT (0.41) | NAMPTPTPRBCA2CA9RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |