Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.39 |
| ▸ | GSK3B | P49841 | 12/20 | 0.39 |
| ▸ | WNT1 | P04628 | 9/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365404 | 0.85 | MEN1 (0.37) | DYRK1AGSK3B | |
| SCHEMBL19365408 | 0.85 | MEN1 (0.37) | DYRK1AGSK3B | |
| SCHEMBL19670463 | 0.84 | EGFR (0.45) | DYRK1AGSK3BKDR | |
| SCHEMBL19364814 | 0.84 | GRM5 (0.38) | DYRK1AGSK3B | |
| SCHEMBL19365399 | 0.84 | PRMT5 (0.40) | DYRK1AGSK3B | |
| SCHEMBL19670441 | 0.84 | GRM5 (0.38) | DYRK1AGSK3B | |
| SCHEMBL17618591 | 0.84 | CCNA2 (0.41) | CCNA2CDK2DYRK1AGSK3BWNT1 | |
| SCHEMBL19365768 | 0.84 | EGFR (0.45) | DYRK1AGSK3BKDR | |
| SCHEMBL19365398 | 0.84 | PRMT5 (0.40) | DYRK1AGSK3B | |
| SCHEMBL19365482 | 0.84 | MCL1 (0.45) | CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |