Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 8/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364814 | 1.00 | GRM5 (0.38) | GRM5DYRK1AGSK3BMTORPIK3CA | |
| SCHEMBL19670463 | 0.86 | EGFR (0.45) | DYRK1AGSK3BMTORPIK3CAMEN1 | |
| SCHEMBL19365768 | 0.86 | EGFR (0.45) | DYRK1AGSK3BMTORPIK3CAMEN1 | |
| SCHEMBL17618589 | 0.85 | PIK3CA (0.41) | GRM5DYRK1AGSK3BMTORPIK3CA | |
| SCHEMBL19670208 | 0.84 | CCNA2 (0.42) | DYRK1AGSK3B | |
| SCHEMBL19365765 | 0.83 | ATR (0.47) | DYRK1AGSK3BMEN1HTTKMT2A | |
| SCHEMBL19365766 | 0.83 | ATR (0.47) | DYRK1AGSK3BMEN1HTTKMT2A | |
| SCHEMBL19365409 | 0.83 | RAB9A (0.41) | GRM5DYRK1AGSK3BMEN1HTT | |
| SCHEMBL19365410 | 0.83 | RAB9A (0.41) | GRM5DYRK1AGSK3BMEN1HTT | |
| SCHEMBL19365399 | 0.83 | PRMT5 (0.40) | GRM5DYRK1AGSK3BMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |