Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 6/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364834 | 0.90 | ALDH1A1 (0.39) | HDAC2ABL1DYRK1AGSK3B | |
| SCHEMBL19365583 | 0.90 | ABL1 (0.38) | HDAC2ABL1DYRK1AGSK3BCYP3A4 | |
| SCHEMBL19706219 | 0.90 | HDAC3 (0.38) | HDAC2HDAC1HDAC3ABL1DYRK1A | |
| SCHEMBL20631935 | 0.90 | HDAC2 (0.35) | HDAC2HDAC1HDAC3ABL1DYRK1A | |
| SCHEMBL19365461 | 0.89 | HDAC1 (0.39) | HDAC2HDAC1HDAC3DYRK1AGSK3B | |
| SCHEMBL19670630 | 0.89 | HDAC1 (0.40) | HDAC2HDAC1HDAC3ABL1DYRK1A | |
| SCHEMBL19364864 | 0.87 | HDAC2 (0.44) | HDAC2HDAC1HDAC3ABL1DYRK1A | |
| SCHEMBL19365703 | 0.86 | PIK3C3 (0.40) | HDAC2HDAC1HDAC3ABL1DYRK1A | |
| SCHEMBL19670617 | 0.84 | MAPK1 (0.42) | HDAC2HDAC1HDAC3ABL1DYRK1A | |
| SCHEMBL19704260 | 0.83 | HDAC2 (0.39) | HDAC2HDAC1HDAC3ABL1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |