Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21841343 | 0.91 | KMO (0.41) | KMOMCHR1POLBRAB9APIK3CD | |
| SCHEMBL19670601 | 0.90 | POLB (0.41) | KMOMCHR1POLBRAB9APIK3CD | |
| SCHEMBL19365769 | 0.90 | MPL (0.43) | MPLKMOCPT2CPT1ACPT1B | |
| SCHEMBL19364807 | 0.89 | ATR (0.35) | MPLPOLBRAB9AKDRCHRNB2 | |
| SCHEMBL19703381 | 0.88 | GRM5 (0.42) | MPLKMOMCHR1MEN1ALDH1A1 | |
| SCHEMBL19365636 | 0.87 | POLB (0.46) | KMOCPT2CPT1ACPT1BMCHR1 | |
| SCHEMBL19670247 | 0.87 | PTGS1 (0.39) | KMOMCHR1POLBRAB9APIK3CD | |
| SCHEMBL19365606 | 0.85 | ATR (0.48) | CPT2CPT1ACPT1BCHRNB2CHRNB4 | |
| SCHEMBL19365569 | 0.85 | MCHR1 (0.41) | CPT2CPT1ACPT1BMCHR1ATR | |
| SCHEMBL19365521 | 0.85 | POLB (0.39) | KMOMCHR1POLBRAB9APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |