Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365429 | 0.92 | POLB (0.36) | POLBRAB9AMCHR1DCUN1D1UBE2M | |
| SCHEMBL19365519 | 0.89 | POLB (0.46) | POLBRAB9AMCHR1EPHX2MEN1 | |
| SCHEMBL19365841 | 0.89 | PIK3CD (0.36) | POLBRAB9AMCHR1PIK3CDPIK3CA | |
| SCHEMBL19365728 | 0.88 | HDAC2 (0.43) | POLB | |
| SCHEMBL19365636 | 0.88 | POLB (0.46) | POLBRAB9AMCHR1PIK3CDPIK3CA | |
| SCHEMBL19365379 | 0.87 | HDAC2 (0.44) | MCHR1 | |
| SCHEMBL19365306 | 0.85 | POLB (0.44) | POLBRAB9AMCHR1EPHX2KDM1A | |
| SCHEMBL19670247 | 0.84 | PTGS1 (0.39) | POLBRAB9AMCHR1PIK3CDPIK3CA | |
| SCHEMBL19670240 | 0.84 | PRMT5 (0.37) | TRPV1 | |
| SCHEMBL19670400 | 0.84 | ATR (0.45) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |