Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 6/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706132 | 0.92 | TRPV3 (0.35) | CRHR1MAP4K4DYRK1A | |
| SCHEMBL19365509 | 0.91 | PHGDH (0.38) | PIK3CDPIK3CAPIK3CGMCHR1KDM1A | |
| SCHEMBL19365506 | 0.90 | UBE2M (0.41) | FYNPOLBRAB9AUBE2MDCUN1D1 | |
| SCHEMBL19670603 | 0.89 | POLB (0.43) | PIK3CDPIK3CAPIK3CGMCHR1KDM1A | |
| SCHEMBL19365547 | 0.89 | ATR (0.35) | MCHR1KDM1AMAOBFYNMAP4K4 | |
| SCHEMBL19670563 | 0.84 | ALOX15 (0.44) | PIK3CDPIK3CAPIK3CGKDM1AMAOB | |
| SCHEMBL19365833 | 0.84 | RHOA (0.43) | PIK3CDPIK3CAPIK3CGFYNPOLB | |
| SCHEMBL19365769 | 0.82 | MPL (0.43) | PIK3CDPIK3CAPIK3CGKDM1AMAOB | |
| SCHEMBL19365643 | 0.82 | KMO (0.36) | PIK3CDPIK3CAPIK3CGMCHR1KDM1A | |
| SCHEMBL19670557 | 0.81 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CGFYNKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |