Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 3/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670401 | 1.00 | MAP4K4 (0.39) | MAP4K4TRPV3EIF2AK4NAMPTALDH1A1 | |
| SCHEMBL19670672 | 0.86 | MAP4K4 (0.46) | MAP4K4TRPV3EIF2AK4IDH2SCN10A | |
| SCHEMBL19670506 | 0.86 | MAP4K4 (0.46) | MAP4K4TRPV3EIF2AK4IDH2SCN10A | |
| SCHEMBL19670500 | 0.85 | MAP4K4 (0.43) | MAP4K4TRPV3EIF2AK4SCN10ABTK | |
| SCHEMBL19670351 | 0.85 | MAP4K4 (0.43) | MAP4K4TRPV3EIF2AK4SCN10ABTK | |
| SCHEMBL19670582 | 0.83 | MAP4K4 (0.42) | MAP4K4TRPV3EIF2AK4SCN10A | |
| SCHEMBL16754312 | 0.82 | TRPV1 (0.41) | MAP4K4TRPV3EIF2AK4NAMPTALDH1A1 | |
| SCHEMBL19670296 | 0.82 | TRPV1 (0.41) | MAP4K4TRPV3EIF2AK4NAMPTALDH1A1 | |
| SCHEMBL19365684 | 0.82 | TRPV1 (0.41) | MAP4K4TRPV3EIF2AK4NAMPTALDH1A1 | |
| SCHEMBL16754618 | 0.82 | TRPV1 (0.41) | MAP4K4TRPV3EIF2AK4NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |