Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 7/20 | 0.40 |
| ▸ | HTR2A | P28223 | 6/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754312 | 1.00 | TRPV1 (0.41) | TRPV1ALDH1A1MAPTHTR2CHTR2A | |
| SCHEMBL19365684 | 1.00 | TRPV1 (0.41) | TRPV1ALDH1A1MAPTHTR2CHTR2A | |
| SCHEMBL16754618 | 1.00 | TRPV1 (0.41) | TRPV1ALDH1A1MAPTHTR2CHTR2A | |
| SCHEMBL17624589 | 0.97 | TRPV1 (0.40) | TRPV1ALDH1A1MAPTHTR2CHTR2A | |
| SCHEMBL20733297 | 0.91 | MAP4K4 (0.42) | MAPTMAP4K4NAMPTTRPV3BTK | |
| SCHEMBL17624239 | 0.90 | MAP4K4 (0.41) | TRPV1MAPTMAP4K4NAMPTTRPV3 | |
| SCHEMBL19365686 | 0.90 | MAP4K4 (0.41) | TRPV1MAPTMAP4K4NAMPTTRPV3 | |
| SCHEMBL16238392 | 0.89 | TRPV1 (0.42) | TRPV1MAPTHTR2CHTR2ANAMPT | |
| SCHEMBL16776498 | 0.88 | ALDH1A1 (0.41) | TRPV1ALDH1A1MAPTHTR2CHTR2A | |
| SCHEMBL19669729 | 0.88 | TRPV1 (0.40) | TRPV1ALDH1A1MAPTHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |