Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.41 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.41 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670400 | 0.90 | ATR (0.45) | ATRPRKCAPRKCQSYKCAMK2D | |
| SCHEMBL19670395 | 0.89 | ATR (0.45) | ATRPRKCAPRKCQSYKPLOD2 | |
| SCHEMBL19670541 | 0.86 | ATR (0.42) | ATRPRKCAPRKCQSYKCAMK2D | |
| SCHEMBL19670525 | 0.86 | ATR (0.45) | ATRPRKCAPRKCQPIK3CASYK | |
| SCHEMBL19670413 | 0.86 | ATR (0.43) | ATRPRKCAPRKCQSYKPLOD2 | |
| SCHEMBL19365604 | 0.85 | HDAC1 (0.46) | ATRNAMPT | |
| SCHEMBL19365310 | 0.84 | TSHR (0.45) | ATRPRKCA | |
| SCHEMBL19365519 | 0.83 | POLB (0.46) | BRAF | |
| SCHEMBL19364819 | 0.82 | MCHR1 (0.47) | ATRPRKCABRAF | |
| SCHEMBL19706031 | 0.81 | CASR (0.44) | ATRSYKCASRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |