Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 4/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670395 | 0.92 | ATR (0.45) | ATRPRKCAPRKCQAKT1JAK2 | |
| SCHEMBL19670413 | 0.92 | ATR (0.43) | ATRPRKCAPRKCQSCN9AAKT1 | |
| SCHEMBL19670541 | 0.91 | ATR (0.42) | ATRPRKCAPRKCQSCN9AAKT1 | |
| SCHEMBL19670643 | 0.86 | ATR (0.47) | ATRPRKCAPRKCQJAK2SYK | |
| SCHEMBL19670248 | 0.86 | ATR (0.41) | ATRPRKCAPRKCQAKT1JAK2 | |
| SCHEMBL19365710 | 0.83 | CNR2 (0.52) | ATR | |
| SCHEMBL19670400 | 0.83 | ATR (0.45) | ATRPRKCAPRKCQAKT1JAK2 | |
| SCHEMBL19365577 | 0.82 | GRM5 (0.38) | ATR | |
| SCHEMBL19670601 | 0.82 | POLB (0.41) | VCPPIK3CAKDM1A | |
| SCHEMBL19364891 | 0.81 | MCHR1 (0.42) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |