Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16064983 | 1.00 | HSD11B1 (0.40) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL16090816 | 1.00 | HSD11B1 (0.40) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL16064855 | 1.00 | HSD11B1 (0.40) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL21013781 | 1.00 | HSD11B1 (0.40) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL16064930 | 0.92 | HSD11B1 (0.39) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL21013698 | 0.92 | HSD11B1 (0.39) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL16034147 | 0.91 | CHRM2 (0.37) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL14343401 | 0.88 | HSD11B1 (0.43) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL18116222 | 0.88 | HSD11B1 (0.43) | HSD11B1CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL18643676 | 0.81 | GRIN2B (0.37) | HSD11B1CHRM2CHRM1CHRM3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252053-B1 | POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS | GILEAD SCIENCES INC (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3252053-A1 | POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS | Gilead Sciences, Inc. (US) | 2017-12-06 | — | — | EP | disclosed |