Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP9 | Q86TI2 | 11/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.47 |
| ▸ | DPP4 | P27487 | 8/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.39 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13068138 | 0.84 | KMT2A (0.41) | DPP9DPP8DPP4DPP7KCNH2 | |
| SCHEMBL13068164 | 0.84 | KMT2A (0.41) | DPP9DPP8DPP4DPP7KCNH2 | |
| SCHEMBL10209346 | 0.77 | DPP9 (0.46) | DPP9DPP8DPP4DPP7KCNH2 | |
| SCHEMBL8228638 | 0.77 | DPP9 (0.47) | DPP9DPP8DPP4DPP7KCNH2 | |
| SCHEMBL14223471 | 0.74 | PDK2 (0.42) | — | |
| SCHEMBL30142417 | 0.74 | DPP9 (0.63) | DPP9DPP8DPP4DPP7PITRM1 | |
| SCHEMBL11434101 | 0.73 | HTR2A (0.42) | DPP4KCNH2TMEM97SIGMAR1FAP | |
| SCHEMBL19700136 | 0.72 | KCNH2 (0.59) | DPP9DPP8DPP4DPP7KCNH2 | |
| SCHEMBL14163034 | 0.72 | KCNH2 (0.47) | DPP9DPP8DPP4DPP7KCNH2 | |
| SCHEMBL10057635 | 0.72 | KCNH2 (0.59) | DPP9DPP8DPP4DPP7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746443-B1 | TRIAZOLOPYRIMIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2022-07-06 | — | — | EP | disclosed |
| WO-2019149660-A1 | TRIAZOLOPYRIMIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-08-08 | — | — | WO | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |