Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.62 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | KIF20A | O95235 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991525 | 0.83 | MAP2K1 (0.71) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL12146963 | 0.83 | MAP2K1 (0.62) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL28169313 | 0.83 | MAP2K1 (0.62) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL13325426 | 0.80 | MAP2K1 (0.68) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL985214 | 0.79 | MAP2K1 (0.71) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL27708260 | 0.79 | MAP2K1 (0.71) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL29468201 | 0.79 | MAP2K1 (0.71) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL4343092 | 0.78 | MAP2K1 (0.60) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| Hydrochloric Acid SCHEMBL3608101 | 0.77 | MAP2K1 (0.69) | MAP2K1AXLGPR84DYRK1AKIF20A | |
| SCHEMBL14406018 | 0.77 | MAP2K1 (0.68) | MAP2K1AXLGPR84DYRK1AKIF20A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |