Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.71 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | KIF20A | O95235 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29468201 | 1.00 | MAP2K1 (0.71) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| Hydrochloric Acid SCHEMBL3608101 | 0.98 | MAP2K1 (0.69) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| Methoxymethane SCHEMBL28146835 | 0.93 | MAP2K1 (0.77) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| SCHEMBL2114977 | 0.90 | ADORA2A (0.67) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| SCHEMBL27708260 | 0.89 | MAP2K1 (0.71) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| Hydrochloric Acid SCHEMBL10655021 | 0.89 | ADORA2A (0.65) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| SCHEMBL1474975 | 0.88 | MAP2K1 (0.65) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| Hydrochloric Acid SCHEMBL3595977 | 0.86 | MAP2K1 (0.63) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| SCHEMBL12647233 | 0.86 | MAP2K1 (0.67) | MAP2K1CAMKK2ADORA2ACNR2AXL | |
| SCHEMBL2991525 | 0.86 | MAP2K1 (0.71) | MAP2K1CAMKK2ADORA2ACNR2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 339 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117343058-A | Substituted 7-azaindole-3-carboxylic acid Mcl-1 protein inhibitor and preparation method and application thereof | 湖南科技大学 | 2024-01-05 | — | — | CN | claimed |
| CN-114054099-B | Fe (Fe) 3 O 4 @SiO 2 -2N-CoCl 2 Catalyst, preparation method and application thereof | 万华化学集团股份有限公司 | 2023-07-11 | — | — | CN | claimed |
| CN-115537083-A | Preparation method and application of high-performance low-VOC (volatile organic compound) composite resin for chrome-free nonmetal tanning | 兴业皮革科技股份有限公司 | 2022-12-30 | — | — | CN | claimed |
| CN-115521693-A | Preparation method of UV-resistant flame-retardant waterproof polyurethane resin and high-grade calf leather | 兴业皮革科技股份有限公司 | 2022-12-27 | — | — | CN | claimed |
| CN-114054099-A | Fe3O4@SiO2-2N-CoCl2Catalyst, preparation method and application thereof | 万华化学集团股份有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-110041328-A | A kind of preparation method of fluoro- 1H- pyrrolo- [2,3-b] pyridine-3-carboxylic acid of 5- | 南京合巨药业有限公司 | 2019-07-23 | — | — | CN | claimed |
| CN-107903261-A | A kind of synthetic method of 7 azaindole, 3 carboxylic acid | 东莞市联洲知识产权运营管理有限公司 | 2018-04-13 | — | — | CN | claimed |
| CN-105753866-A | 4-halo-7-azaindole and preparation method thereof | 叶芳 | 2016-07-13 | — | — | CN | claimed |
| CN-105218546-A | The synthesis technique of 1H-pyrrolo-[2,3-B] pyridine-3-carboxylic acid methyl esters | SHANGHAI TITAN TECHNOLOGY CO LTD | 2016-01-06 | — | — | CN | claimed |
| EP-1888579-B1 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA SA (FR) | 2011-08-03 | — | — | EP | claimed |
| US-7674795-B2 | Fluorene derivatives, composition containing said derivatives and the use thereof | AVENTIS PHARMA SA (FR) | 2010-03-09 | — | — | US | claimed |
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-06-26 | — | — | US | claimed |
| CN-1247576-C | Novel 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation | ELBION AG (DE) | 2006-03-29 | — | — | CN | claimed |
| EP-1330455-B1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2005-08-03 | — | — | EP | claimed |
| US-20040106641-A1 | Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | BIOTIE THERAPIES GMBH (DE) | 2004-06-03 | — | — | US | claimed |
| CN-1484644-A | Novel 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation | �����ɷ� | 2004-03-24 | — | — | CN | claimed |
| EP-1149098-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 7-AZAINDOLYL-3-CARBOXYLIC ACID | Dompé S.P.A. (IT) | 2001-10-31 | — | — | EP | claimed |
| WO-2000029411-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 7-AZAINDOLYL-3-CARBOXYLIC ACID | DOMPE' SPA (IT) | 2000-05-25 | — | — | WO | claimed |
| US-12617785-B2 | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | THE ROCKEFELLER UNIVERSITY (US) | 2026-05-05 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12617785-B2 | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | YAP1, LATS2, LATS1 | MAP2K1 871/4885CAMKK2 43/4885ADORA2A 3422/4885 |
| US-20040106641-A1 | Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | PDE4A, PDE4B, PDE4C | MAP2K1 2469/4885CAMKK2 912/4885ADORA2A 518/4885 |
| US-20080153837-A1 | Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof | HSP90B1, HSP90AB1, HSP90AA1 | MAP2K1 3928/4885CAMKK2 1470/4885ADORA2A 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.