Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196599 | 0.82 | KMT2A (1.00) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL8315301 | 0.82 | KMT2A (1.00) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL954146 | 0.82 | KMT2A (0.76) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL954303 | 0.81 | KMT2A (0.73) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL2937795 | 0.81 | KMT2A (0.73) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL13494276 | 0.80 | KMT2A (0.68) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL24655998 | 0.78 | MAPK1 (0.74) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL12789839 | 0.78 | KMT2A (0.69) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL11267017 | 0.78 | KMT2A (0.69) | KMT2AKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL17321376 | 0.78 | KMT2A (0.69) | KMT2AKDM4EALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |