Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.42 |
| ▸ | WNT3A | P56704 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19676568 | 0.79 | KDM4E (0.53) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL18858493 | 0.76 | KDM4E (0.61) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL19675209 | 0.73 | KDM4E (0.57) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL7349349 | 0.70 | KDM4E (0.66) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL217086 | 0.69 | KDM4E (0.67) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL12441826 | 0.69 | KDM4E (0.57) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL29781840 | 0.69 | KDM4E (0.67) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL498053 | 0.69 | KDM4E (1.00) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL8232893 | 0.69 | KDM4E (0.61) | KDM4ESTAT3HIF1AYTHDC1FLT3 | |
| SCHEMBL29805260 | 0.69 | KDM4E (1.00) | KDM4ESTAT3HIF1AYTHDC1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |