Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675209 | 0.80 | KDM4E (0.57) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL18858493 | 0.79 | KDM4E (0.61) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL19675153 | 0.79 | MAP2K4 (0.48) | FLT3MAP4K1 | |
| SCHEMBL19675476 | 0.79 | KDM4E (0.53) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL25139723 | 0.77 | KDM4E (0.48) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL217086 | 0.73 | KDM4E (0.67) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL12441826 | 0.73 | KDM4E (0.57) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL29781840 | 0.73 | KDM4E (0.67) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL2704442 | 0.72 | SMN1; SMN2 (0.71) | KDM4EYTHDC1STAT3HIF1AFLT3 | |
| SCHEMBL7668372 | 0.72 | KDM4E (0.66) | KDM4EYTHDC1STAT3HIF1AFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |