SCHEMBL19675508

SCHEMBL19675508

CC(CO)Sc1nnc(S)s1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2329960 0.79 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2
SCHEMBL8770476 0.78 ALDH1A1 (0.37) ALDH1A1SMN1; SMN2
SCHEMBL11617926 0.78 NPC1 (0.43) ALDH1A1SMN1; SMN2
SCHEMBL9713508 0.74 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2
SCHEMBL1959315 0.73 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2
SCHEMBL16168916 0.73 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2
SCHEMBL9383704 0.72 ALDH1A1 (0.40) ALDH1A1
SCHEMBL20681834 0.72 NPC1 (0.39) ALDH1A1SMN1; SMN2
SCHEMBL2117230 0.72 ALDH1A1 (0.41) ALDH1A1
SCHEMBL9385778 0.70 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2685980-B1 METHODS AND USE OF BIFUNCTIONAL ENZYME-BUILDING CLAMP-SHAPED MOLECULES UNIV PENNSYLVANIA (US) 2017-12-06 EP disclosed