Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYBB | P04839 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959585 | 0.81 | IDO1 (0.48) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL27918261 | 0.80 | IDO1 (0.52) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL31297773 | 0.80 | IDO1 (0.52) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL23673718 | 0.79 | IDO1 (0.50) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL24029284 | 0.78 | IDO1 (0.42) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL12187940 | 0.77 | IDO1 (0.44) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL29092445 | 0.73 | IDO1 (0.52) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL12571712 | 0.69 | IDO1 (0.52) | IDO1HSD17B10GLAMEN1KMT2A | |
| SCHEMBL15933851 | 0.69 | MAPT (0.46) | MAPTMAPK1BCHE | |
| SCHEMBL38664322 | 0.67 | IDO1 (0.38) | IDO1HSD17B10GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |