Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | Q9HBH1 | 2/20 | 0.38 | |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28131846 | 0.87 | NOX1 (0.42) | NOX1BCHELMNAMAPTMAPK1 | |
| SCHEMBL28168110 | 0.86 | NOX1 (0.41) | NOX1BCHELMNAGSK3BMAOA | |
| Hydrochloric Acid SCHEMBL28771874 | 0.83 | BCHE (0.42) | NOX1BCHELMNAMAPTMAPK1 | |
| SCHEMBL32662573 | 0.73 | MAOA (0.43) | NOX1BCHEMAPTL3MBTL1GSK3B | |
| SCHEMBL12264201 | 0.72 | MAOA (0.46) | NOX1BCHEL3MBTL1GSK3BMAOA | |
| SCHEMBL27645758 | 0.71 | BCHE (0.39) | NOX1BCHELMNAMAPTMAPK1 | |
| SCHEMBL3738688 | 0.71 | MAPT (0.47) | NOX1BCHELMNAMAPTMAPK1 | |
| SCHEMBL347425 | 0.71 | MAOA (0.45) | NOX1BCHEL3MBTL1GSK3BMAOA | |
| SCHEMBL29814962 | 0.71 | MAOA (0.45) | NOX1BCHEL3MBTL1GSK3BMAOA | |
| SCHEMBL16728889 | 0.71 | MAOA (0.45) | NOX1BCHEL3MBTL1GSK3BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |