Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16442100 | 0.86 | NOS2 (0.31) | NOS2 | |
| SCHEMBL19308504 | 0.86 | PDE10A (0.32) | NOS2 | |
| SCHEMBL24466695 | 0.81 | GRM4 (0.40) | NOS2 | |
| SCHEMBL19835245 | 0.81 | GRM4 (0.40) | NOS2 | |
| SCHEMBL27772975 | 0.78 | PDK2 (0.41) | — | |
| SCHEMBL24165636 | 0.78 | NOS2 (0.40) | NOS2 | |
| SCHEMBL23978663 | 0.75 | KDM5A (0.31) | — | |
| SCHEMBL18597002 | 0.69 | PDE10A (0.31) | — | |
| SCHEMBL13348654 | 0.68 | MEN1 (0.33) | — | |
| SCHEMBL22002024 | 0.68 | EGFR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-B1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-02-26 | — | — | EP | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |