Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.66 |
| ▸ | SYK | P43405 | 5/20 | 0.66 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15584963 | 0.86 | SYK (0.64) | AURKASYKCHEK1NTRK2CDK5 | |
| SCHEMBL655996 | 0.80 | SYK (1.00) | AURKASYKJAK2JAK3NTRK2 | |
| SCHEMBL10228970 | 0.78 | SYK (0.89) | AURKASYKJAK2JAK3NTRK2 | |
| SCHEMBL655648 | 0.76 | SYK (0.92) | AURKASYKJAK2JAK3NTRK2 | |
| SCHEMBL28504300 | 0.76 | JAK3 (0.63) | AURKASYKBRD4JAK2JAK1 | |
| SCHEMBL15585044 | 0.76 | SYK (0.54) | AURKASYKCHEK1NTRK2STK17A | |
| SCHEMBL19675784 | 0.76 | MERTK (0.54) | AURKASYKBRD4JAK2JAK1 | |
| SCHEMBL653706 | 0.76 | SYK (0.72) | AURKASYKBRD4JAK2JAK1 | |
| SCHEMBL19654299 | 0.75 | BRD4 (0.67) | AURKASYKBRD4JAK2JAK1 | |
| SCHEMBL19654300 | 0.75 | BRD4 (0.67) | AURKASYKBRD4JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2840080-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF | FUJIFILM CORP (JP) | 2017-12-06 | — | — | EP | disclosed |